Insights & thinking

The Comet Clinical blog

Perspectives on clinical research, real-world evidence, and what it takes to deliver great science remotely.

Latest post CRO Operations

The Hidden Costs of Over-Engineering Low-Risk Studies

More process does not equal better science — especially for low-risk observational and nutritional studies. The hidden costs of over-engineering are often larger than the visible ones.

29th August 2026 6 min Read more
CRO Operations

The Hidden Costs of Over-Engineering Low-Risk Studies

More process does not equal better science — especially for low-risk observational and nutritional studies. The hidden costs of over-engineering are often larger than the visible ones.

29th August 2026 6 min
Read more
Nutritional Research

Patient Recruitment in Nutritional Research: Strategies That Actually Work

Recruitment is consistently one of the biggest challenges in nutritional research. The problem is rarely a shortage of eligible people — it is a gap between who is eligible and who actually consents and shows up.

1st August 2026 7 min
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Study Design

Five Common Mistakes in Observational Study Design (and How to Avoid Them)

The gap between a well-designed and a poorly designed observational study is not always obvious from the outside — but only one produces evidence robust enough to support decisions. Here are five mistakes that separate the two.

18th July 2026 7 min
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CRO Operations

Remote-First Research: How Distributed CRO Models Reduce Cost Without Cutting Corners

A genuinely remote-first CRO is built differently from one that has simply added distributed working on top of existing structures. Here's what that difference looks like in practice — and why it matters for study quality.

4th July 2026 6 min
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Study Design

The Case for Non-CTIMP Studies: When Proportionate Regulation Delivers Better Science

Over-regulating low-risk research drives up cost without improving science. Understanding when non-CTIMP governance applies — and what it enables — is one of the most valuable things a sponsor can do before a study begins.

20th June 2026 7 min
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CRO Operations

Why the Traditional CRO Model Is Broken — and How to Fix It

Bloated, logistics-intensive CROs drive up costs and complexity. Here's how a lean, data-first alternative delivers better evidence for clinical and real-world studies.

13th May 2026 5 min
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Real-World Evidence

From Steps to Insights: How Wearables Are Powering Real-World Evidence

Connected wearables transform everyday life into rich, real-world data that can unlock deeper, more continuous evidence about how treatments work outside the clinic.

10th March 2026 7 min
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